Top Ranked California Hospitals
1. City of Hope Comprehensive Cancer Center – Duarte, CA
U.S. News 2024-2025 National Rank for Cancer: Top 5 in the Nation
Key Specialties: Hematologic Malignancies (Leukemia, Lymphoma, Myeloma), Stem Cell Transplants, Immunotherapy and CAR T-cell Therapy, Breast, Prostate, and Lung Cancer Surgery.
City of Hope is now among the Top 5 cancer hospitals in the entire nation. It is renowned for its exceptional quality of care, its deep expertise in blood cancers, and its groundbreaking work as one of the country's most active centers for cellular and gene-modified therapies. It is an NCI-designated Comprehensive Cancer Center.
2. UCSF Health - UCSF Medical Center – San Francisco, CA
U.S. News 2024-2025 National Rank for Cancer: #7 in the Nation
Key Specialties: Hematologic Malignancies (Leukemia, Lymphoma, Myeloma), Pancreatic Cancer, Brain and Spinal Cord Tumors, Pediatric Cancer, Cancer Genetics and Genomic Medicine.
UCSF is a highly elite hospital, often ranked as the #1 overall hospital in California and a national Top 10 center for cancer. It holds the distinction of being the highest-ranked cancer hospital in Northern California. UCSF is known for its strengths in hematologic cancers, neuro-oncology, and innovative genomic medicine.
3. UCLA Health - Ronald Reagan UCLA Medical Center – Los Angeles, CA
U.S. News 2024-2025 National Rank for Cancer: Top 15 in the Nation
Key Specialties: Breast, Prostate, and Lung Cancer, Brain and Spinal Cord Tumors, Gynecologic Cancer, Immunotherapy and Cell Therapy, Surgical Oncology (Minimally Invasive Techniques).
UCLA Health is an elite, nationally-ranked center, frequently tied for the top overall hospital in the state. It is recognized for its cutting-edge research, its broad expertise across solid tumors, and offering comprehensive multidisciplinary care. It is an NCI-designated Comprehensive Cancer Center.
4. Stanford Health Care - Stanford Hospital – Stanford, CA
U.S. News 2024-2025 National Rank for Cancer: Top 25 in the Nation
Key Specialties: Brain Tumors and Neurological Cancers, Lung and Ovarian Cancer, Immunotherapy and Experimental Treatments, Gene Editing and Gene Therapy Research.
Stanford is a major research engine and a global leader in cancer genomics, cell therapy, and experimental treatments. It is especially renowned for its expertise in treating neurological cancers and its ability to rapidly translate scientific discoveries into patient care.
5. Cedars-Sinai Medical Center – Los Angeles, CA
U.S. News 2024-2025 National Rank for Cancer: Highly Rated
Key Specialties: Gastrointestinal Cancers (Liver, Pancreatic), Lung Cancer, Melanoma and Skin Cancer, Cancer Genetics and Precision Medicine.
Cedars-Sinai is a high-ranking hospital overall (tied for #1 in California) and nationally recognized for its cancer program. It is highly regarded for its work in gastrointestinal cancers and its cutting-edge Precision Medicine program.
6. UC San Diego Health - Moores Cancer Center – San Diego, CA
U.S. News 2024-2025 National Rank for Cancer: Highly Rated
Key Specialties: Breast Cancer, Lung Cancer, Colorectal Cancer, Cancer Genetics and Counseling, Immunotherapy and Clinical Trials.
Why It's Ranked #6: Moores Cancer Center is a leading NCI-designated Comprehensive Cancer Center in the San Diego region. It is a key regional center for breast cancer, lung cancer, and GI cancers, with a strong focus on cancer genetics, prevention, and clinical trials.
7. Keck Medicine of USC Norris Comprehensive Cancer Center – Los Angeles, CA
U.S. News 2024-2025 National Rank for Cancer: Highly Rated
Key Specialties: Lung Cancer, Leukemia and Lymphoma, Pediatric Cancer, Cancer Genetics and Genomic Medicine, Immunotherapy and Targeted Therapy.
Why It's Ranked #7: USC Norris is an NCI-designated Comprehensive Cancer Center providing highly specialized care in pediatric cancer, lung cancer, and hematologic malignancies. It offers a wide range of services including genetic counseling and targeted therapies.
8. Scripps MD Anderson Cancer Center – San Diego, CA
U.S. News 2024-2025 National Rank for Cancer: Highly Rated
Key Specialties: Breast, Lung, and Prostate Cancer, Melanoma, Immunotherapy and Clinical Trials.
Why It's Ranked #8: This center is a unique partnership combining the renowned expertise of the #1-ranked cancer hospital in the nation (MD Anderson) with the patient-centered care model of Scripps Health.
9. Rady Children's Hospital Cancer Center – San Diego, CA
U.S. News 2024-2025 National Rank: Specialized Pediatric Center
Key Specialties: Pediatric Leukemia and Lymphoma, Brain Tumors (in children), Solid Tumors (e.g., Neuroblastoma).
Why It's Ranked #9: Rady Children's focuses exclusively on childhood cancers. It is recognized for its leading programs in pediatric oncology and brain tumors and provides specialized research and care for children across Southern California.
10. Saint John's Cancer Institute – Santa Monica, CA
U.S. News 2024-2025 National Rank: Highly Rated Regional Center
Key Specialties: Breast, Lung, and Colon Cancer, Melanoma, Genetic Testing and Counseling, Experimental Cancer Treatments.
Why It's Ranked #10: A highly respected specialized regional center known for treating breast, lung, and colon cancers. It focuses on highly personalized care, advanced surgical techniques, and access to select clinical trials.
Ranking Based on the 2024-2025 U.S. News & World Report Best Hospitals for CA