🏛️ Federal & National Registries
ClinicalTrials.gov (Modernized)
- Website: clinicaltrials.gov
- Description: The primary U.S. government database. 2026 Update: The site now uses an "Enhanced Search" that allows you to filter by "Distance from Zip Code" and "Virtual/Decentralized" participation options.
National Cancer Institute (NCI)
- Website: cancer.gov/about-cancer/treatment/clinical-trials
- Description: The authoritative source for NCI-funded research. It includes a specific directory for NCI-Designated Cancer Centers, which often host the most cutting-edge Phase I and II trials.
American Cancer Society (ACS) – ACS ACTS
- Website: acts.cancer.org
- Description: Beyond just a search tool, their ACTS program provides one-on-one specialists to help patients overcome barriers like cost or travel that often prevent trial enrollment.
🧬 Precision Medicine & Specialized Research
My Cancer Genome
- Website: mycancergenome.org
- Description: Essential for Precision Medicine. It matches patients to trials based on specific genetic mutations (like KRAS, EGFR, or ALK) rather than just the cancer's location.
Cancer Research Institute (CRI)
- Website: cancerresearch.org/clinical-trials
- Description: The headquarters for Immunotherapy trials. If you are looking for CAR T-cell therapy or cancer vaccines, start here.
National Comprehensive Cancer Network (NCCN)
- Website: nccn.org
- Description: A coalition of the 33 top cancer centers in the US. They provide the "Gold Standard" guidelines that oncologists use to determine if a patient should move from standard care to a trial.
🤝 Patient Support & Navigation Services
Patient Advocate Foundation (PAF)
- Website: patientadvocate.org
- Description: Focuses on the financial and legal side. They help ensure your insurance covers the "routine costs" of being in a clinical trial.
AccessHope
- Website: myaccesshope.org
- Description: A newer service that connects community doctors with experts from "National Cancer Institute" centers to identify trials that may not be locally advertised.
Clinical Trials For All
- Website: clinicaltrialsforall.org
- Description: A patient-first advocacy site that breaks down "trial-speak" into plain English and offers educational videos on what to expect during a study.
🩸 Blood Cancer & Transplant Specifics
Be The Match (NMDP)
- Website: bethematch.org
- Description: Specifically for Leukemia, Lymphoma, and Sickle Cell. They focus on trials involving bone marrow and cord blood transplants.
HealthTree Foundation
- Website: healthtree.org
- Description: A high-tech platform for blood cancer patients. It allows you to track your own labs and see which trials other patients with your exact "profile" are joining.
🏥 University & Industry Resources
OncoLink (University of Pennsylvania)
- Website: oncolink.org
- Description: One of the oldest and most reliable internet cancer resources. Their "OncoLife" tool helps create a personalized plan for trial survivors.
Eli Lilly – Cancer Resources
🧭 Summary Checklist for 2026
StepAction:
1. Get your Biomarker/Genomic Report (Needed for My Cancer Genome).
2. Check ClinicalTrials.gov for local proximity.
3. Contact ACS ACTS if you need help with travel or lodging.
4. Ask your oncologist: "Is there a decentralized version of this trial so I can do labs locally?"